Cardiopulmonary complications induced by Iranian Mesobuthus eupeus scorpion venom in anesthetized rabbits
نویسندگان
چکیده
منابع مشابه
First transcriptome analysis of Iranian scorpion, Mesobuthus eupeus venom gland
Scorpions are generally an important source of bioactive components, including toxins and other small peptides as attractive molecules for new drug development. Mesobuthus eupeus, from medically important and widely distributed Buthidae family, is the most abundant species in Iran. Researchers are interesting on the gland of this scorpion due to the complexity of its venom. Here, we have analyz...
متن کاملInhibition of Nephrotoxic Activity of Mesobuthus Eupeus Scorpion Venom by Commercial Polyvalent Antivenom in Rabbits
Background: Immunotherapy is the only specific treatment for scorpion envenomation. In the present study, the protective effects of polyvalent antivenom against histopathological complications in kidneys and marker changes (BUN and creatinine) induced by Mesobuthus eupeus (Me) scorpion venom was investigated in anesthetized rabbits. Methods: Twenty four rabbits were randomized into four gro...
متن کاملFirst transcriptome analysis of Iranian scorpion, Mesobuthus eupeus venom gland
Scorpions are generally an important source of bioactive components, including toxins and other small peptides as attractive molecules for new drug development. Mesobuthus eupeus, from medically important and widely distributed Buthidae family, is the most abundant species in Iran. Researchers are interesting on the gland of this scorpion due to the complexity of its venom. Here, we have analyz...
متن کاملBiochemical and Histopathological study of Mesobuthus eupeus scorpion venom in the experimental rabbits
In tropical and subtropical countries, envenomation by scorpions (so-called scorpionism) represents a serious public health problem. In the present study, the toxic effects of mice LD50 injections of Mesobuthus eupeus (Me) venom on the kidney and liver of anesthetized rabbits were investigated. Six rabbits were selected and ALT, AST, BUN and creatinine were measured at 0, 1 and 3 hours after...
متن کاملNeutralizing effects of polyvalent antivenom on severe inflammatory response induced by Mesobuthus eupeus scorpion venom
This study evaluated the effects of Mesobuthus eupeus (Me) scorpion venom on inflammatory response following injection. Additionally, the present study examined whether immunotherapy at specific time intervals would be effective on inflammatory response after Me venom inoculation. Animals were divided randomly into four groups: the first group received LD50 of venom and the second and third gro...
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ژورنال
عنوان ژورنال: Journal of Venomous Animals and Toxins including Tropical Diseases
سال: 2010
ISSN: 1678-9199
DOI: 10.1590/s1678-91992010005000001